The Journal

Insights on wellness

Evidence-based articles on metabolic health, GLP-1 science, and building sustainable habits for a healthier life.

How GLP-1 medications actually work — and why they're different

Semaglutide and tirzepatide don't just suppress appetite. They change how your brain responds to food signals at a hormonal level.

Week by week: appetite changes, scale movement, and the adjustment period most programs don't tell you about.

You don't need a restrictive diet to see results. But there are a few things that can dramatically speed up your progress.

A clinical breakdown of how these two medications compare — and the questions to ask your provider.